Teaching NeuroImages: Cerebral syphilitic gumma with numerous spirochetes in immunohistochemical staining

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Cerebral Syphilitic Gumma in Immunocompetent Man, Japan

Although cerebral syphilitic gummas are generally considered to be rare manifestations of tertiary syphilis, many reports exist of early cerebral syphilitic gumma. Our finding of cerebral syphilitic gumma in an HIV-negative man within 5 months after syphilis infection suggests that this condition should be considered in syphilis patients who have neurologic symptoms.

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Cerebral Syphilitic Gumma Misdiagnosed as a Malignant Brain Tumor.

Syphilitic gumma involvement of the central nervous system is extremely rare and frequently misdiagnosed. The authors report a patient of a cerebral syphilitic gumma resembling a malignant brain tumor in a 62-year-old male. He was first suspected of a malignant brain tumor, but the pathological diagnosis was cerebral syphilitic gumma. This patient with unusual findings illustrates the clinical ...

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Cerebral Syphilitic Gumma within 5 Months of Syphilis in HIV-Infected Patient

1. Yip CC, Lau SK, Woo PC, Yuen KY. Human enterovirus 71 epidemics: what’s next? Emerg Health Threats J. 2013;6:19780. http://dx.doi.org/10.3402/ehtj.v6i0.19780 2. Brown BA, Oberste MS, Alexander JP Jr, Kennett ML, Pallansch MA. Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998. J Virol. 1999;73:9969–75. 3. McMinn PC. Recent advances in the molecular epid...

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Cerebral syphilitic gumma mimicking malignant brain tumor in a human immunodeficiency virus-negative patient

Cerebral syphilitic gumma is considered an uncommon involvement of the brain during tertiary syphilis and the differentiation from a brain mass in HIV-negative patients with syphilis is still challengeable to clinicians. We report an unusual case of cerebral syphilitic gumma mimicking malignant brain tumor in a human immunodeficiency virus-negative patient. A 41-year old man complaining of head...

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The patient was a 24-year-old man who presented with a 2-month history of headache, gait disturbance and hearing loss. He had no skin or genital manifestations before these symptoms. T2-weighted magnetic resonance imaging (MRI), fluid-attenuated inversion recovery MRI, contrast-enhanced T1-weighted MRI, and diffusion-weighted MRI revealed a mass with extensive edema and dural enhancement in the...

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ژورنال

عنوان ژورنال: Neurology

سال: 2018

ISSN: 0028-3878,1526-632X

DOI: 10.1212/wnl.0000000000005029